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TETEC: What is NOVOCART™Disc?

November 2009. The disc-cell product NOVOCART™Disc is a cell suspension aiming a biological treatment of human intervertebral disc defects.
The autologous disc-cell product NOVOCART™Disc is characterized by:
·    High cell viability
·    Individual manufacture for each patient
·    Use of autologous sera
·    Synthesis of most important matrix components (type II collagen and aggrecan)
·    Synthesis of most important growth- and differentiation factors
·    No over-expression of inflammatory cytokines (interleukin-1ß or dedifferentiation markers (type I collagen)
·    Manufacture an delivery within two weeks from cartilage harvest
·    No supplementation of antibiotics or antimicotics
The biological intervertebral disc reconstruction
The Autologous Disc Cell Transplantation (ADCT = transplantation of intervertebral disc cells cultured in vitro) is at present the only method, which allows a biological reconstruction of a partially destroyed or damaged intervertebral disc. The ADCT is very similar to the ACT for the knee joint with respect to its indication and impact. For both procedures the desired effect, i.e. the biological reconstruction, is produced by cells isolated from a biopsy and cultured in laboratory.
Description of the ADCT with NOVOCART™DISC
The transplantation of the cultivated cells takes place three months after harvesting the intervertebral disc biopsy. This quite long time lapse between biopsy harvest and transplantation is necessary to allow healing of the outer ring  (annulus fibrosus) of the intervertebral disc in order to regain a disc-containment.

 

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